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Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin
Abstract
The aim of the performed study was to fabricate an antibacterial and degradable scaffold that may be used in the field of skin regeneration. To reach the degradation criterion for the biocompatible polyurethane (PUR), obtained by using amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), was used and processed with so-called “fast-degradable” polymer polylactide (PLA) (5 or 10 wt %). To meet the antibacterial requirement obtained, hybrid PUR-PLA scaffolds (HPPS) were modified with ciprofloxacin (Cipro) (2 or 5 wt %) and the fluoroquinolone antibiotic inhibiting growth of bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, which are the main causes of wound infections. Performed studies showed that Cipro-modified HPPS, obtained by using 5% of PLA, possess suitable mechanical characteristics, morphology, degradation rates, and demanded antimicrobial properties to be further developed as potential scaffolds for skin tissue engineering.
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Polymers
no. 12,
pages 1 - 18,
ISSN: 2073-4360 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Carayon I., Terebieniec A., Łapiński M., Filipowicz N., Kucińska-Lipka J.: Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin// Polymers -Vol. 12,iss. 1 (2020), s.1-18
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/polym12010171
- Sources of funding:
-
- This work was supported by the Gdansk University of Technology, Narutowicza St. 11/12, 80-233 Gdansk, Poland, Internal Funding No. 033206
- Verified by:
- Gdańsk University of Technology
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