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Cyclodextrin polymers as efficient adsorbents for removing toxic non-biodegradable pimavanserin from pharmaceutical wastewaters
Abstract
Presence of even small amount of active pharmaceutical ingredients in the environment carries risks tohuman and animal health, presenting an important issue. The paper presents issues related to the newdrug - pimavanserin (PMV). Biological treatment efficiency of pimavanserin (PMV) was evaluated usinglab-scale Sequencing Batch Reactor (SBR). It has been shown to have a negative effect on aquatic or-ganisms by classifying it as a toxic compound (EC50¼8 mgL1). The level of biological degradation ofPMV was insufficient (37%) and intensively foam formation caused operational problems. For this reason,in this study polymers based on cyclodextrins (CDs) were synthesized and used as adsorbents alternativeto active carbons to effectively separate PMV from real industrial waste streams. Crosslinkedb- andg-CDpolymers (b- andg-NS), obtained in reaction with 1,10-carbonyldiimidazole (CDI), were fully character-ized by physicochemical methods. The adsorption equilibrium data were interpreted using Freundlichand Langmuir models. The sorption process was fast (60 s) and the efficiency of PMV separation frommodel waste waters was 93% and 81% forb- andg-NS, respectively. Maximum polymer capacity wasfound at 52.08 mg g1forb-NS and 23.26 mg g1forg-NS. The interactions of PMV with CDs have beenstudied and indicate that major mechanism of the sorption is based on supramolecular interaction andcapture to polymer network. Described biodegradable and reusable materials are perfect example ofcorrectly selected adsorbent for separation of target substance from postproduction aqueous media
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
CHEMOSPHERE
no. 250,
ISSN: 0045-6535 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Hemine K., Skwierawska A., Kernstein A., Kozłowska-Tylingo K.: Cyclodextrin polymers as efficient adsorbents for removing toxic non-biodegradable pimavanserin from pharmaceutical wastewaters// CHEMOSPHERE -Vol. 250, (2020), s.126250-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.chemosphere.2020.126250
- Sources of funding:
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- Politechnika Gdańska: DS 033150
- Verified by:
- Gdańsk University of Technology
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