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Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
Abstract
Based on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
Authors (3)
-
Iwona Inkielewicz-Stępniak
- GUMed Katedra Chemii Medycznej
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Details
- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Przybyłowska M., Dzierzbicka K., Inkielewicz-Stępniak I.: Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents// / : , 2020,
- Verified by:
- Gdańsk University of Technology
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