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Development of a High-Sensitivity Triple-Band Nano-Biosensor Utilizing Petahertz Metamaterials for Optimal Absorption in Early-Stage Leukemia Detection
Abstract
This research focuses on designing a novel miniaturized biosensor for early-stage detection of leukemia. The proposed sensor operates in the low Petahertz (PHz) range. The primary prerequisites for the development process include multi-band operation, compact physical size, near-perfect absorption at resonant frequencies, and insensitivity to the angle of incidence. These features are crucial for ensuring high-performance operation in microwave imaging (MWI) and have been achieved through meticulous design of the absorber's geometry and dimensions. The sensor incorporates a dipole and two rings made of gold or silver, implanted on a silicon dioxide dielectric substrate with a fully metallic backplane. The evolution of the biosensor's topology is detailed, along with comprehensive simulation studies conducted using a commercial full-wave electromagnetic (EM) solver. The operating principles are explained through parametric studies, analysis of absorption and refraction characteristics, and discussions of electric and magnetic fields, as well as surface current density distributions. The device’s suitability for blood cancer diagnostics is demonstrated through full-wave analysis of the MWI system, highlighting the sensor’s ability to discriminate between healthy and cancerous samples through noticeable frequency shifts in absorption responses. Extensive comparisons with the state-of-the-art biosensors reported in recent literature show that the proposed device significantly improves spectral properties and achieves remarkable spatial resolution due to its PHz range operation when compared to the benchmark.
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Authors (9)
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Musa N. Hamza
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Mohammad Tariqul Islam
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Sunil Lavadiva
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Iftikhar Din Un
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Bruno Sanches
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Seyda Iffat Naqvi
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Ali Farmani
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Shabiul Islam
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1109/JSEN.2025.3544761
- License
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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IEEE SENSORS JOURNAL
no. 25,
pages 13955 - 13973,
ISSN: 1530-437X - Language:
- English
- Publication year:
- 2025
- Bibliographic description:
- Hamza M. N., Islam M. T., Lavadiva S., Din Un I., Sanches B., Kozieł S., Naqvi S. I., Farmani A., Islam S.: Development of a High-Sensitivity Triple-Band Nano-Biosensor Utilizing Petahertz Metamaterials for Optimal Absorption in Early-Stage Leukemia Detection// IEEE SENSORS JOURNAL -Vol. 25,iss. 8 (2025), s.13955-13973
- DOI:
- Digital Object Identifier (open in new tab) 10.1109/jsen.2025.3544761
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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