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Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells
Abstract
In the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry. The experimental results were supported by calculations on the threshold energies of formed anions and transition state calculations. We show that low-energy electrons with kinetic energies near 0 eV may effectively decompose the molecule upon DEA. The by far most abundant anion observed corresponds to the iodine anion (I-). Due to the associated bond cleavage, a radical site is formed at the C5 position, which may initiate strand break formation if the molecule is incorporated into a DNA strand. Our results reflect the conclusion from previous radiolysis studies with the title compound, suggesting its potential as a radiosensitizer.
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Authors (8)
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Muhammad Saqib
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Eugene Arthur-Baidoo
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Farhad Izadi
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Adrian Szczyrba
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Magdalena Datta mgr inż.
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Janusz Rak Prof.
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Stephan Denifl
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpclett.3c02219
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Journal of Physical Chemistry Letters
no. 14,
pages 8948 - 8955,
ISSN: 1948-7185 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Saqib M., Arthur-Baidoo E., Izadi F., Szczyrba A., Datta M., Demkowicz S., Rak J., Denifl S.: Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells// Journal of Physical Chemistry Letters -,iss. 14 (40) (2023), s.8948-8955
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpclett.3c02219
- Sources of funding:
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- Free publication
- Verified by:
- Gdańsk University of Technology
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