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Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
Abstract
OBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated test tubes containing saline. Needles from group II were immersed (one by one) for 5 seconds in a set of 12 test tubes containing saline. Then, each solution was analyzed using high-performance liquid chromatography. The results were compared with the susceptibility break points for Escherichia coli. Group III was incubated with E coli strains on Mueller-Hinton plate and then the bacterial inhibition zones surrounding needles were measured. RESULTS: The average concentration of antibiotics eluted from needles (group I) was 361.98 ± 15.36 µg/mL for amikacin and 63.87 ± 5.95 µg/mL for ciprofloxacin. The chromatographic analysis revealed the gradual release of both antibiotics from needles (group II). The concentration of amikacin released from needles exceeded the break-point value from first to ninth immersion. Ciprofloxacin concentration was higher than break-point value in all immersions. The average bacterial inhibition zone minor axis was 42 ± 5.7 mm (group III). CONCLUSIONS: The use of drug-eluting biopsy needle could be a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. This study confirmed its biological activity as well as the gradual release of antibiotics from its surface. Confirmation of its preventive role, in terms of infectious complications after transrectal prostate biopsy, has to be evaluated in a clinical trial.
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Authors (7)
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Marcin Sieczkowski
- Department of Urology, Medical University of Gdańsk
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Artur Gibas
- Department of Urology, Medical University of Gdańsk
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Lidia Piechowicz
- Department of Microbiology, Medical University of Gdańsk
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1177/1533034617722080
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
no. 16,
edition 6,
pages 1038 - 1043,
ISSN: 1533-0346 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Sieczkowski M., Gibas A., Wasik A., Kot-Wasik A., Piechowicz L., Namieśnik J., Matuszewski M.: Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy// TECHNOLOGY IN CANCER RESEARCH & TREATMENT. -Vol. 16, iss. 6 (2017), s.1038-1043
- DOI:
- Digital Object Identifier (open in new tab) 10.1177/1533034617722080
- Verified by:
- Gdańsk University of Technology
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