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Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications
Abstract
Magnesium phosphate cement (MPC) is a suitable alternative for the currently used calcium phosphates, owing to beneficial properties like favorable resorption rate, fast hardening, and higher compressive strength. However, due to insufficient mechanical properties and high brittleness, further improvement is still expected. In this paper, we reported the preparation of a novel type of dual-setting cement based on MPC with poly(2-hydroxyethyl methacrylate) (pHEMA). The aim of our study was to evaluate the effect of HEMA addition, especially its concentration and premix time, on the selected properties of the composite. Several beneficial effects were found: better formability, shortened setting time, and improvement of mechanical strengths. The developed cements were hardening in ∼16–21 min, consisted of well-crystallized phases and polymerized HEMA, had porosity between ∼2–11%, degraded slowly by ∼0.1–4%/18 days, their wettability was ∼20–30°, they showed compressive and bending strength between ∼45–73 and 13–20 MPa, respectively, and, finally, their Young’s Modulus was close to ∼2.5–3.0 GPa. The results showed that the optimal cement composition is MPC+15%HEMA and 4 min of polymer premixing time. Overall, our research suggested that this developed cement may be used in various biomedical applications.
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Authors (4)
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Anna Ronowska dr hab. n. med.
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Uwe Gbureck prof.
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsami.3c14491
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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ACS Applied Materials & Interfaces
no. 15,
pages 55533 - 55544,
ISSN: 1944-8244 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Wekwejt M., Khamenka M., Ronowska A., Gbureck U.: Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications// ACS Applied Materials & Interfaces -Vol. 15,iss. 48 (2023), s.55533-55544
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsami.3c14491
- Sources of funding:
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- Free publication
- Verified by:
- Gdańsk University of Technology
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