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Exploring the Antitumor Efficacy of N-Heterocyclic Nitrilotriacetate Oxidovanadium(IV) Salts on Prostate and Breast Cancer Cells
Abstract
The crystal structures of two newly synthesized nitrilotriacetate oxidovanadium(IV) salts, namely [QH][VO(nta)(H2O)](H2O)2 (I) and [(acr)H][VO(nta)(H2O)](H2O)2 (II), were determined. Additionally, the cytotoxic effects of four N-heterocyclic nitrilotriacetate oxidovanadium(IV) salts— 1,10-phenanthrolinium, [(phen)H][VO(nta)(H2O)](H2O)0.5 (III), 2,2′-bipyridinium [(bpy)H][VO(nta)(H2O)](H2O) (IV), and two newly synthesized compounds (I) and (II)—were evaluated against prostate cancer (PC3) and breast cancer (MCF-7) cells. All the compounds exhibited strong cytotoxic effects on cancer cells and normal cells (HaCaT human keratinocytes). The structure–activity relationship analysis revealed that the number and arrangement of conjugated aromatic rings in the counterion had an impact on the antitumor effect. The compound (III), the 1,10-phenanthrolinium analogue, exhibited the greatest activity, whereas the acridinium salt (II), with a different arrangement of three conjugated aromatic rings, showed the lowest toxicity. The increased concentrations of the compounds resulted in alterations to the cell cycle distribution with different effects in MCF-7 and PC3 cells. In MCF-7 cells, compounds I and II were observed to block the G2/M phase, while compounds III and IV were found to arrest the cell cycle in the G0/G1 phase. In PC3 cells, all compounds increased the rates of cells in the G0/G1 phase.
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Authors (6)
-
Katarzyna Chmur
- Wydział Chemii, Uniwersytet Gdański
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Aleksandra Tesmar
- Wydział Chemii, Uniwersytet Gdański
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Magdalena Zdrowowicz
- Wydział Chemii, Uniwersytet Gdański
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Dariusz Wyrzykowski
- Wydział Chemii, Uniwersytet Gdański
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Full text
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/molecules29122924
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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MOLECULES
no. 29,
ISSN: 1420-3049 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Chmur K., Tesmar A., Zdrowowicz M., Rosiak D., Chojnacki J., Wyrzykowski D.: Exploring the Antitumor Efficacy of N-Heterocyclic Nitrilotriacetate Oxidovanadium(IV) Salts on Prostate and Breast Cancer Cells// MOLECULES -Vol. 29,iss. 12 (2024), s.2924-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/molecules29122924
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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