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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma

Abstract

Introduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with skin melanoma, who were candidates for sentinel node biopsy were enrolled in our study. All patients underwent simultaneous use of standard nanocolloid and blue dye. Transcutaneous visualization of the sentinel node, visualization of lymphatic channels as well as sentinel node fl uorescent visualization were all measured. We also performed calculations of Signal to Background ratios (SBR). Results: In 15% (3/20) of patients, the fl uorescent sentinel node was visible through the skin. The median SBR for the sentinel node visualization by fl uorescence was 3.15 (range, 2.7 – 3.5). Lymphatic channels were visible in lymphatic tissue via fl uorescence before visualization by the naked eye in 4 patients (20%). The median SBR ratio was 3.69 (range, 2.7 – 4.2). Sentinel nodes were visible by fl uorescence in 13 cases (65%). The median SBR ratio was 2.49 (range, 1.5 – 5.7). No factors were found to be associated with fl uorescent MB visualization of a sentinel node during biopsy. Conclusion: This is the fi rst clinical study presenting the usefulness of fl uorescent sentinel node biopsy in melanoma patients using MB as a fl uorophore. Further studies are necessary to provide methods for its ’ clinical implementation.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Surgical Innovation no. 29,
ISSN: 1553-3506
Language:
English
Publication year:
2022
Bibliographic description:
Cwalinski T., Skokowski J., Polom W., Marano L., Swierblewski M., Drucis K., Roviello G., Cwalina N., Kalinowski L., Roviello F., Polom K.: Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma// Surgical Innovation -Vol. 29,iss. 4 (2022), s.155335062210746-
DOI:
Digital Object Identifier (open in new tab) 10.1177/15533506221074601
Sources of funding:
  • Free publication
Verified by:
Gdańsk University of Technology

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