Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation

Sophie Grellet; Małgorzata Śmiałek-Telega; Nigel J. Mason; Jon Golding

doi:10.1088/1742-6596/875/5/042013

Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation

Abstract

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics

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Authors (4)

Sophie Grellet
- School of Life, Health and Chemical Sciences The Open University
Małgorzata Śmiałek-Telega dr hab. inż.
Nigel J. Mason
- School of Physical Sciences The Open University
Jon Golding
- School of Life, Health and Chemical Sciences The Open University

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DOI:: Digital Object Identifier (open in new tab) 10.1088/1742-6596/875/5/042013
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Category:: Conference activity
Type:: materiały konferencyjne indeksowane w Web of Science
Published in:: Journal of Physics : Conference Series no. 875, pages 1 - 2,
ISSN: 1742-6588
Title of issue:: Journal of Physics: Conf. Series strony 1 - 2
Language:: English
Publication year:: 2017
Bibliographic description:: Grellet S., Śmiałek-Telega M., Mason N. J., Golding J..: Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation, W: Journal of Physics: Conf. Series, 2017, ,.
DOI:: Digital Object Identifier (open in new tab) 10.1088/1742-6596/875/5/042013
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