Identification of synergistic and antagonistic actions of environmental pollutants: Bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE·2HCl in three component mixtures - Publication - Bridge of Knowledge

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Identification of synergistic and antagonistic actions of environmental pollutants: Bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE·2HCl in three component mixtures

Abstract

Ecosystems are facing increased pressure due to the emission of many classes of emerging contaminants. However, very little is known about the interactions of these pollutants, such as bisphenols (BPs), plasticizers or pharmaceuticals. By employing bioluminescent bacteria (Microtox assay), we were able to define interactions between selected emerging pollutants (namely BPA, BPS, BPF, BADGE, BADGE·2HCl, DEP, DBP) in ternary mixtures, at environmentally relevant concentration levels (down to as low as 1.89, 1.42, 3.08, and 0.326 μM for, respectively, BPA, BPF, BPS and BADGE·2HCl).Weprovide the first systematic analysis of bisphenols and phthalates in three component mixtures. Using this system, we performed toxicity modelling with concentration addition (CA) and independent action (IA) approaches, followed by data interpretation using Model Deviation Ratio (MDR) evaluation. Interestingly, we mathematically and experimentally confirmed a novel synergy between BPA, BADGE and BADGE·2HCl. The synergy of BPA, BADGE and BADGE·2HCl is distinct, with both models suggesting these analytes have a similar mode of action (MOA).

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
SCIENCE OF THE TOTAL ENVIRONMENT no. 767,
ISSN: 0048-9697
Language:
English
Publication year:
2021
Bibliographic description:
Jatkowska N., Kudłak B., Lewandowska P., Liu W., Williams M., Schiöth H.: Identification of synergistic and antagonistic actions of environmental pollutants: Bisphenols A, S and F in the presence of DEP, DBP, BADGE and BADGE·2HCl in three component mixtures// SCIENCE OF THE TOTAL ENVIRONMENT -Vol. 767, (2021), s.144286-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.scitotenv.2020.144286
Sources of funding:
  • IDUB 1/2020/IDUB/I.3.2
Verified by:
Gdańsk University of Technology

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