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Abstract
The mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore, the mammalian cardiomyocyte withdraw from the cell cycle seems to be the biggest barrier for the regeneration in adult organisms. Hence, the analysis of the mechanisms that guide this transition in the neonatal life may be employed to awake the dormant regenerative potential of the heart. In this paper the recent findings on the neonatal heart regeneration have been presented.
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- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- PhD Interdisciplinary Journal. - No. 2 strony 127 - 130
- Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Górnikiewicz B., Podolak-Popinigis J.: Insight into heart regeneration// PhD Interdisciplinary Journal. - No. 2/ ed. M. Czubenko : GUT, 2013, s.127-130
- Verified by:
- Gdańsk University of Technology
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