Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ

Ethienne Castellucci Estevam; Sharoon Griffin; Muhammad Jawad Nasim; Dariusz Zieliński; Justyna Aszyk; Magdalena Osowicka; Natalia Dawidowska; Rinaldi Idroes; Agnieszka Bartoszek-Pączkowska; Claus Jacob

doi:10.1177/1934578x1501001025

Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ

Abstract

The last decade has witnessed a renewed interest in antimicrobial agents. Plants have received particular attention and frequently rely on the spontaneous enzymatic conversion of an inactive precursor to an active agent. Such two-component substrate/enzyme defence systems can be reconstituted ex vivo. Here, the alliin/alliinase system from garlic seems to be rather effective against Saccharomyces cerevisiae, whilst the glucosinolate/myrosinase system from mustard appears to be more active against certain bacteria. Studies with myrosinase also confirm that enzyme and substrate can be added sequentially. Ultimately, such binary systems hold considerable promise and may be employed in a medical or agricultural context.

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Authors (10)

Ethienne Castellucci Estevam
- Department of Pharmacy Saarland University Bioorganic Chemistry
Sharoon Griffin
- Department of Pharmacy Saarland University Bioorganic Chemistry
Muhammad Jawad Nasim
- Department of Pharmacy Saarland University Bioorganic Chemistry
Dariusz Zieliński
Justyna Aszyk
Magdalena Osowicka
Natalia Dawidowska
Rinaldi Idroes
- Syiah Kuala University Pharmacy Department Chemistry Department
Agnieszka Bartoszek-Pączkowska prof. dr hab. inż.
Claus Jacob
- Department of Pharmacy Saarland University Bioorganic Chemistry

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DOI:: Digital Object Identifier (open in new tab) 10.1177/1934578x1501001025
License: Copyright (2015 SAGE Publications)

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: Natural Product Communications no. 10, pages 1733 - 1738,
ISSN: 1934-578X
Language:: English
Publication year:: 2015
Bibliographic description:: Estevam E., Griffin S., Nasim M., Zieliński D., Aszyk J., Osowicka M., Dawidowska N., Idroes R., Bartoszek-Pączkowska A., Jacob C.: Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ// Natural Product Communications. -Vol. 10, nr. 10 (2015), s.1733-1738
DOI:: Digital Object Identifier (open in new tab) 10.1177/1934578x1501001025
Verified by:: Gdańsk University of Technology