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Abstract
The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobial agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, as well as valuable anticancer activity, proving beneficial in the development of anticancer conjugates. The resulting conjugates offer potential dual functionality, acting as both an anticancer and an antimicrobial agent. This is especially necessary in cancer treatment, where microbial infections pose a critical risk. Leukemic cells frequently exhibit altered outer lipid membranes compared to healthy cells, making them more sensitive to compounds that interfere with their membrane. In this study, we revisited and reanalyzed our earlier research on LfcinB and its conjugates. Furthermore, we carried out new experiments with a specific focus on cell proliferation, changes in membrane asymmetric phosphatidylserine location, intracellular reactive oxygen species (ROS) generation, mitochondrial functions, and in vitro bacterial topoisomerase inhibition.
Citations
Authors (12)
-
Jan Lica dr
-
Katarzyna Gucwa Dr inż.
-
Mateusz Heldt
-
Anna Stupak
-
Natalia Ptaszyńska
-
Anna Łęgowska
-
Bhaskar Pradhan
-
Agata Gitlin-Domagalska
-
Dębowski Dawid
-
Joanna Jakóbkiewicz-Banecka dr hab.
-
Rolka Krzysztof
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
MOLECULES
no. 29,
ISSN: 1420-3049 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Lica J., Gucwa K., Heldt M., Stupak A., Maciejewska N., Ptaszyńska N., Łęgowska A., Pradhan B., Gitlin-Domagalska A., Dawid D., Jakóbkiewicz-Banecka J., Krzysztof R.: Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity// MOLECULES -,iss. 29(3) (2024), s.678-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/molecules29030678
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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