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Abstract
Aspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H mutation (34 bp tandem repeats in the promotor region and single point mutations of cyp 51A gene resulting in the substitution of leucine for histidine in lanosterol 14 alpha-demethylase). It is suggested that the overuse of some fungicides in agriculture contribute to the selection of resistant mutants. The avian farms seems to be places of higher risk of contamination and subsequent infection caused by resistant Aspergillus fumigatus strains.
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Authors (5)
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Alina Wieliczko Profesor dr hab.
- Uniwersytet Przyrodniczy we Wrocławiu
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Keywords
Details
- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Title of issue:
- 8th Trends in Medical Mycology, Organised under the auspices of EORTC-IDG and ECMM strony 62 - 62
- Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Nawrot U., Wieliczko A., Włodarczyk K., Kurzyk E., Brillowska-Dąbrowska A.: Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates// 8th Trends in Medical Mycology, Organised under the auspices of EORTC-IDG and ECMM/ : , 2017, s.62-62
- DOI:
- Digital Object Identifier (open in new tab) 10.1111/myc.12674
- Verified by:
- Gdańsk University of Technology
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