Search
Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
Abstract
Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease (CAD) patients and 151 healthy controls, in association with estab-lished risk factors for CVD (sex, age, hypertension, smoking, diabetes, glomerular filtration rate [GFR]) and troponin, an established marker of CAD. MtDNAcn was significantly lower in CAD patients; it correlates with GFR and TMA, but not with TMAO. A biomarker including mtDNAcn, sex, and hypertension (but neither TMA nor TMAO) emerged as a good predictor of CAD. Our findings support the mtD-NAcn as a promising plastic biomarker, useful to monitor the exposure to risk factors and the efficacy of preventive interventions for a personalized CAD risk reduction.
Citations
-
2 1
CrossRef
-
0
Web of Science
-
2 0
Scopus
Authors (10)
-
Laura Bordoni
-
Irene Petracci
-
Iwona Pelikant-Malecka
-
Adrianna Radulska
-
Marco Piangerelli
-
Joanna J. Samulak
-
Lukasz Lewicki
-
Rosita Gabbianelli
-
Robert A. Olek
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1096/fj.202100056R
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
FASEB JOURNAL
no. 35,
ISSN: 0892-6638 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Bordoni L., Petracci I., Pelikant-Malecka I., Radulska A., Piangerelli M., Samulak J. J., Lewicki L., Kalinowski L., Gabbianelli R., Olek R. A.: Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers// FASEB JOURNAL -, (2021),
- DOI:
- Digital Object Identifier (open in new tab) 10.1096/fj.202100056r
- Verified by:
- Gdańsk University of Technology
seen 91 times
Recommended for you
Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
- L. Bordoni,
- J. J. Samulak,
- A. K. Sawicka
- + 6 authors
Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients
- L. Bordoni,
- D. Fedeli,
- M. Piangerelli
- + 8 authors
Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
- A. Owczarczyk-Saczonek,
- D. Purzycka-Bohdan,
- B. Nedoszytko
- + 22 authors
B35 The Significance The Level Of Mitochondrial Dna In Huntington's Disease
- P. J drak,
- S. Bara ska,
- M. Krygier
- + 6 authors