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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
Abstract
In this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the development of novel, non-toxic, and endowed with an analgesic activity anticancer drugs. More preclinical and clinical studies are needed to explore these opportunities.
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Authors (5)
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Justyna Budka mgr
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Szymon Kowalski mgr inż.
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Monika Chylińska mgr
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Iwona Inkielewicz-Stępniak
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- Copyright (2020 Bentham Science Publishers)
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
CURRENT MEDICINAL CHEMISTRY
no. 28,
pages 673 - 686,
ISSN: 0929-8673 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Budka J., Kowalski S., Chylińska M., Dzierzbicka K., Inkielewicz-Stępniak I.: Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds// CURRENT MEDICINAL CHEMISTRY -Vol. 28,iss. 4 (2021), s.673-686
- DOI:
- Digital Object Identifier (open in new tab) 10.2174/0929867327666200304122406
- Verified by:
- Gdańsk University of Technology
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