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Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells
Abstract
Perfluorooctanoic acid (PFOA) has been widely documented to affect various aspects of health, including development, metabolism and neuronal function in a variety of organisms. Despite numerous reports detailing these effects, a comprehensive mechanistic model remains elusive, especially with regard to the long-term effects of PFOA, as it bioaccumulates in food chains with a long half-life. In this study, we evaluated the impact of PFOA on several critical physiological states of Drosophila melanogaster. Our findings indicate that PFOA exposure significantly decreases reproductive capacity and induces alterations in starvation resistance and feeding behavior in flies. Interestingly, PFOA exposure also caused changes in locomotor activity and sleep patterns compared with flies receiving a standard diet. Notably, compared with controls, the F2 generation showed increased locomotion and shorter sleep duration during the dark phase, even without direct exposure to PFOA, indicating possible transgenerational effects.
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Authors (11)
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Sifang Liao
- Uppsala University, Uppsala, Sweden
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Chengxi Sun
- Uppsala University, Uppsala, Sweden
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Francisco Alejandro Lagunas-Rangel
- Uppsala University, Uppsala, Sweden
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Wen Liu
- Uppsala University, Uppsala, Sweden
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Shiyao Yi
- Uppsala University, Uppsala, Sweden
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Dalia Browne-Johnson
- Uppsala University, Uppsala, Sweden
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Filippa Eklund
- Uppsala University, Uppsala, Sweden
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Ying Zhang
- Qilu Hospital of Shandong University, Jinan, China
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Michael Williams
- Uppsala University, Uppsala, Sweden
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Helgi B. Schiöth
- Uppsala University, Uppsala, Sweden
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.scitotenv.2024.177472
- License
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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SCIENCE OF THE TOTAL ENVIRONMENT
no. 957,
ISSN: 0048-9697 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Liao S., Sun C., Lagunas-Rangel F. A., Liu W., Yi S., Browne-Johnson D., Eklund F., Zhang Y., Kudłak B., Williams M., Schiöth H. B.: Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells// SCIENCE OF THE TOTAL ENVIRONMENT -Vol. 957, (2024), s.177472-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.scitotenv.2024.177472
- Sources of funding:
-
- Statutory activity/subsidy
- Verified by:
- Gdańsk University of Technology
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