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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
Abstract
Background: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis with the use of “Enzyme(s) action” and fragmentomic analysis of theoretical products was performed using “Profiles of potential biological activity” in BIOPEP-UWM database of bioactive peptides. Bioactivity probability calculation and toxicity prediction of the peptides obtained were estimated using PeptideRanker and ToxinPred tools, respectively. Results: Our results showed that the keratins are a potential source of a variety of biopeptides, including dipeptidyl peptidase IV, angiotensin converting enzyme, prolyl endopeptidase inhibitory and antioxidative. Papain and subtilisin were found to be the most appropriate enzymes for keratin hydrolysis. This study presents possible structures of keratin-derived bioactive peptides that have not been previously described. Conclusion: Our data suggest additional in vitro and in vivo studies to verify theoretical predictions and further investigate the possibility of using keratin-rich waste as a source of peptide nutraceuticals.
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- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.2174/1381612828999220114150201
- License
- Copyright (2022 Bentham Science Publishers)
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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CURRENT PHARMACEUTICAL DESIGN
no. 28,
pages 841 - 851,
ISSN: 1381-6128 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Taraszkiewicz A., Sinkiewicz I., Sommer A., Dąbrowska M., Staroszczyk H.: Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach// CURRENT PHARMACEUTICAL DESIGN -Vol. 28,iss. 10 (2022), s.841-851
- DOI:
- Digital Object Identifier (open in new tab) 10.2174/1381612828999220114150201
- Verified by:
- Gdańsk University of Technology
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