Preparation of 1-[Ω-(1,4,5,6-Tetrahydropyrimidin-2-yl)alkyl]thymines

Jaroslaw Spychala

doi:https://doi.org/10.1080/00397910008087413

Preparation of 1-[Ω-(1,4,5,6-Tetrahydropyrimidin-2-yl)alkyl]thymines

Abstract

One-stage prepn. of the hydrochloride salts of 1-[ω-(1,4,5,6-tetrahydropyrimidin-2-yl)alkyl]-thymines, e.g. I, from 1-(ω-cyanoalkyl)thymines and a 1:1-mixt. of 1,3-diaminopropane and ethanol satd. with hydrogen sulfide is described. 1-(2-Cyanoethyl)-thymine gave a facile reversal of the Michael reaction to thymine under the conditions used. The reaction of 1,3-bis(3-cyanobenzyl)thymine with the above reagent produced 1,3-bis[3-(1,4,5,6-tetrahydropyrimidin-2-yl)benzyl]thymine.

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Jaroslaw Spychala dr

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Category:: Magazine publication
Type:: Magazine publication
Published in:: SYNTHETIC COMMUNICATIONS no. 30, edition 14, pages 2497 - 2506,
ISSN: 0039-7911
Publication year:: 2000
Bibliographic description:: Jaroslaw Spychala, Preparation of 1-[Ω-(1,4,5,6-Tetrahydropyrimidin-2-yl)alkyl]thymines, Synthetic Communications, vol. 30(14), pages 2497-2506, 2000.
DOI:: Digital Object Identifier (open in new tab) https://doi.org/10.1080/00397910008087413
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