Search
Preparation of Pseudopeptides Building Blocks with Retro-Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid
Abstract
An easy and efficient synthesis of pseudo tripeptide containing a thiomalonamide moiety was developed. Isothiocyanate derivatives of amino acids react smoothly with 2,2-dimethyl-1,3-dioxane-4,6-dione yielding new thiocarbamoyl Meldrum's acids. Thermal decomposition of this new Meldrum's acid derivatives generate thiocarbamoyl ketenes, which acylate amino acid esters to give pseudo tripeptides.
Authors (3)
Cite as
Full text
download paper
downloaded 7 times
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/hlca.201100347
- License
- Copyright (2012 Verlag Helvetica Chimica Acta AG, Zrich)
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
HELVETICA CHIMICA ACTA
no. 95,
pages 461 - 468,
ISSN: 0018-019X - Language:
- English
- Publication year:
- 2012
- Bibliographic description:
- Janikowska K., Makowiec S., Rachoń J.: Preparation of Pseudopeptides Building Blocks with Retro-Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid// HELVETICA CHIMICA ACTA. -Vol. 95, nr. iss. 3 (2012), s.461-468
- Verified by:
- Gdańsk University of Technology
seen 102 times