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Preparation of Pseudopeptides Building Blocks with Retro-Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid
Abstract
An easy and efficient synthesis of pseudo tripeptide containing a thiomalonamide moiety was developed. Isothiocyanate derivatives of amino acids react smoothly with 2,2-dimethyl-1,3-dioxane-4,6-dione yielding new thiocarbamoyl Meldrum's acids. Thermal decomposition of this new Meldrum's acid derivatives generate thiocarbamoyl ketenes, which acylate amino acid esters to give pseudo tripeptides.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/hlca.201100347
- License
- Copyright (2012 Verlag Helvetica Chimica Acta AG, Zrich)
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
HELVETICA CHIMICA ACTA
no. 95,
pages 461 - 468,
ISSN: 0018-019X - Language:
- English
- Publication year:
- 2012
- Bibliographic description:
- Janikowska K., Makowiec S., Rachoń J.: Preparation of Pseudopeptides Building Blocks with Retro-Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid// HELVETICA CHIMICA ACTA. -Vol. 95, nr. iss. 3 (2012), s.461-468
- Verified by:
- Gdańsk University of Technology
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