Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells

Shantikumar Nair; Abhilash Sasidharan; V.V. Divya Rani; Deepthy Menon; Seema Nair; K Manzoor; Satish Raina

doi:10.1007/s10856-008-3548-5

Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells

Abstract

The specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia coli) as well as using Gram-positive bacteria (Staphylococcus aureus). Scanning electron microscopy (SEM) was conducted to characterize any visual features of the biocidal action of ZnO. We observed that antibacterial activity increased with reduction in particle size. Toxicity toward the human cancer cell line was considerably higher than previously observed by other researchers on the corresponding pri- mary cells, suggesting selective toxicity of the ZnO to cancer cells. Surface capping was also found to profoundly influence the toxicity of ZnO nanoparticles toward the cancer cell line, with the toxicity of starch-capped ZnO being the lowest. Our results are found to be consistent with a membrane-related mechanism for nanoparticle toxicity toward microbes.

Citations

3 9 4

CrossRef
0

Web of Science
5 3 3

Scopus

Authors (7)

Shantikumar Nair
Abhilash Sasidharan
V.V. Divya Rani
Deepthy Menon
Seema Nair
K Manzoor
Satish Raina prof. dr
- Faculty of Chemistry
- Gdańsk University of Technology

Cite as

Full text

full text is not available in portal

full content of the article see on external site open in new tab

Keywords

Details

Category:: Articles
Type:: artykuły w czasopismach
Published in:: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE no. 20,
ISSN: 0957-4530
Language:: English
Publication year:: 2009
Bibliographic description:: Nair S., Sasidharan A., Rani V. D., Menon D., Nair S., Manzoor K., Raina S.: Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells// JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE -Vol. 20, (2009), s.S235-
DOI:: Digital Object Identifier (open in new tab) 10.1007/s10856-008-3548-5
Verified by:: Gdańsk University of Technology