Sensitive simultaneous determination of 19 fluorobenzoic acids in saline waters by solid-phase extraction and liquid chromatography–tandem mass spectrometry - Publication - Bridge of Knowledge

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Sensitive simultaneous determination of 19 fluorobenzoic acids in saline waters by solid-phase extraction and liquid chromatography–tandem mass spectrometry

Abstract

A solid-phase extraction (SPE) procedure using C18 stationary phase was optimized for the preconcentration of 19 fluorinated derivatives of benzoic acid (FBA): mono-, di-, tri-, and tetrafluorosubstituted in the ring, trifluoromethylbenzoic acid and 3,5-bistrifluoromethyl benzoic acid from undiluted salt-rich (>20%) reservoir waters. Quantitative (>90%) retention/elution of 16 out of 19 analyte compounds was achieved allowing a fourfold preconcentration factor accompanied by the elimination of >99% of salt. For the three most polar compounds (2,6-dFBA, 2,3,6-tFBA, and 2,4,6-tFBA) the non-quantitative recoveries (>70%) were corrected by dedicated custom-synthesized deuterated internal standards. The FBAs were determined by HPLC – MS/MS revisited in terms of a choice of column, elution conditions and MS/MS signal acquisition parameters allowing the baseline separation and a gain in sensitivity. For a sample intake of 4 mL, detection limits for all the compounds in a reservoir water sample containing more than 20% salt were between 0.01 and 0.05 ng/mL which represents a gain of a factor of 10–20 in comparison with the state-of the art LC–MS/MS procedures for samples of similar complexity.

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DOI:
Digital Object Identifier (open in new tab) 10.1016/j.chroma.2015.09.024
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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
JOURNAL OF CHROMATOGRAPHY A no. 1417, pages 30 - 40,
ISSN: 0021-9673
Language:
English
Publication year:
2015
Bibliographic description:
Kubica P., Garraud H., Szpunar J., Lobinski R.: Sensitive simultaneous determination of 19 fluorobenzoic acids in saline waters by solid-phase extraction and liquid chromatography–tandem mass spectrometry// JOURNAL OF CHROMATOGRAPHY A. -Vol. 1417, (2015), s.30-40
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.chroma.2015.09.024
Verified by:
Gdańsk University of Technology

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