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Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome
Abstract
The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0.202 ng/mL [0.150; 0.255] vs. 0.154 ng/ mL [0.106; 0.201], P=0.035), which correlated positively with serum total testosterone (TST) (R=0.285, P=0.004) and the free androgen index (FAI) (R=0.196, P=0.049). There were no significant correlations between serum BPA and BMI, waist circumference, serum glucose, insulin and lipids. These results point to the potential role of BPA in the pathogenesis of the ovarian hyperandrogenism in women with PCOS.
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Authors (8)
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Aleksandra Konieczna
- GUM Department of Clinical and Experimental Endocrinology
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Dominik Rachoń
- GUM Department of Clinical and Experimental Endocrinology
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Agnieszka Kowalewska
- Outpatient Gynecological Practice Outpatient Gynecological Practice
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
REPRODUCTIVE TOXICOLOGY
no. 82,
pages 32 - 37,
ISSN: 0890-6238 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Konieczna A., Rachoń D., Owczarek K., Kubica P., Kowalewska A., Kudłak B., Wasik A., Namieśnik J.: Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome// REPRODUCTIVE TOXICOLOGY. -Vol. 82, (2018), s.32-37
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.reprotox.2018.09.006
- Verified by:
- Gdańsk University of Technology
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