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Sodium alginate decreases the permeability of intestinal mucus

Abstract

In the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations below 0.1%. Despite this lack of interaction between the mucin and alginate, the addition of alginate had a marked effect on the diffusion of 500 nm probe particles, which decreased as a function of increasing alginate concentration. Finally, we passed a protein stabilised emulsion through a simulation of oral, gastric and small intestinal digestion. We subsequently showed that the addition of 0.1% alginate to porcine intestinal mucus decreased the diffusion of fluorescently labelled lipid present in the emulsion digesta. This reduction may be sufficient to reduce problems associated with high rates of lipid absorption such as hyperlipidaemia.

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Authors (8)

  • Photo of  Alan Mackie

    Alan Mackie

    • Norwich Research Park Institute of Food Research
  • Photo of  Kristi Aarak

    Kristi Aarak

    • UMB – Norwegian University of Life Sciences Department of Chemistry, Biotechnology and Food Science (IKBM)
  • Photo of  Neil Rigby

    Neil Rigby

    • Norwich Research Park Institute of Food Research
  • Photo of  Roger Parker

    Roger Parker

    • Norwich Research Park Institute of Food Research
  • Photo of  Guy Channell

    Guy Channell

    • University of Nottingham National Centre for Macromolecular Hydrodynamics
  • Photo of  Stephen Harding

    Stephen Harding

    • University of Nottingham National Centre for Macromolecular Hydrodynamics
  • Photo of  Balazs Bajka

    Balazs Bajka

    • Norwich Research Park Institute of Food Research

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
FOOD HYDROCOLLOIDS no. 52, pages 749 - 755,
ISSN: 0268-005X
Language:
English
Publication year:
2016
Bibliographic description:
Mackie A., Macierzanka A., Aarak K., Rigby N., Parker R., Channell G., Harding S., Bajka B.: Sodium alginate decreases the permeability of intestinal mucus// FOOD HYDROCOLLOIDS. -Vol. 52, (2016), s.749-755
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.foodhyd.2015.08.004
Verified by:
Gdańsk University of Technology

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