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Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected Pd(II) complexes
Abstract
This paper presents the synthesis of two new (p-cymene)-ruthenium(II) complexes with the bidentate coumarin ligands. Both complexes were characterized by FTIR spectroscopy, 1H NMR, 13C NMR, MS, elemental analysis and DFT calculations. The X-ray structure of complex 3a was also solved. The cytotoxic properties of both complexes were examined on human leukemia NALM-6 and HL-60 cells and melanoma WM-115 cells. The complexes possess higher cytotoxic activity than the ligands, The results of DFT calculations performed at the BP86-D3/QZ4P level for Ru(II) complexes and Pd(II) complexes with the same ligands indicate that Pd(II) complexes are more lipophilic. Moreover the RP-TLC-Based Lipophilicity assessment was also performed.
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Authors (8)
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Anna Skoczynska
- Medical University of Lodz Faculty of Pharmacy
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Karin Lux
- Ludwig-Maximilians-University Department of Chemistry
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Peter Mayer
- Ludwig-Maximilians-University Department of Chemistry
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Ingo-Peter Lorenz
- Ludwig-Maximilians-University Department of Chemistry
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Urszula Krajewska
- Medical University of Lodz Faculty of Pharmacy
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Marek Rozalski
- Medical University of Lodz Faculty of Pharmacy
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Elzbieta Budzisz
- Medical University of Lodz Faculty of Pharmacy
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
INORGANICA CHIMICA ACTA
no. 456,
pages 105 - 112,
ISSN: 0020-1693 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Skoczynska A., Lux K., Mayer P., Lorenz I., Krajewska U., Rozalski M., Dołęga A., Budzisz E.: Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected Pd(II) complexes// INORGANICA CHIMICA ACTA. -Vol. 456, (2017), s.105-112
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ica.2016.10.036
- Verified by:
- Gdańsk University of Technology
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