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Structural patterns and cytotoxic activity of dinuclear Cu(II), Ni(II) and Cd(II) complexes with pyridine-based malonic acid dihydrazone
Abstract
A dinuclear Cu(II) complex, [Cu2(L)(H2L)](ClO4)2·4H2O (Cu-1), with a condensation derivative of 2-acetylpyridine and malonic acid dihydrazide (H2L), was obtained through a direct synthesis. After recrystallization, the single-crystalline product was characterized by single crystal X-ray diffraction analysis, EPR, UV/Vis and IR spectroscopy. In the resulting dimeric Cu(II) complex, one ligand molecule is coordinated in its dianionic form, while the other is coordinated in its neutral form. Both ligands adopt a bis-tridentate coordination mode through an NNO donor atom set. Perchlorate ions and water molecules are in the outer coordination sphere, consistent with the conductometric measurement. The coordination geometry around the Cu(II) ion is distorted octahedral. Comparative structural analysis using FIM (Full interaction map) methodology and Hirshfeld surface analysis, along with 2D fingerprint plots of intermolecular interactions revealed significant structural differences among Cu-1 and previously synthesized Ni(II) complexes [Ni2(HL)H2L](ClO4)3∙3DMSO (Ni-1) and [Ni2(H2L)2](ClO4)4∙4DMSO·EtOH (Ni-2), as well as Cd(II) complex [Cd2(H2O)2(H2L)2](ClO4)4·4H2O (Cd-1). Finally, the cytotoxic activities of these dinuclear complexes were evaluated with comparisons drawn based on their half-maximal inhibitory concentration values.
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Authors (9)
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Predag G. Ristić
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Marko Rodić
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Andrej Lj. Milivojac
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Pregelj Matej
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Miloš Ognjanović
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Nenad R. Filipović
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Tamara R. Todorović
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
POLYHEDRON
no. 275,
ISSN: 0277-5387 - Language:
- English
- Publication year:
- 2025
- Bibliographic description:
- Ristić P. G., Maciejewska N., Kallingal A., Rodić M., Milivojac A. L., Matej P., Ognjanović M., Filipović N. R., Todorović T. R.: Structural patterns and cytotoxic activity of dinuclear Cu(II), Ni(II) and Cd(II) complexes with pyridine-based malonic acid dihydrazone// POLYHEDRON -,iss. 275 (2025), s.117523-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.poly.2025.117523
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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