Synthesis of 2-amino-2,6-dideoxy-D-glucitol-6-sulfonic acid as a potential antifungal agent.

Kornelia Skarbek

Synthesis of 2-amino-2,6-dideoxy-D-glucitol-6-sulfonic acid as a potential antifungal agent.

Abstract

Glucosamine-6P (GlcN-6P) synthase catalyzes the ﬁrst committed step in the biosynthetic pathway leading to the formation of UDP-GlcNAc, a sugar nucleotide precursor providing D-glucosamine for the formation of chitin and manoproteins. 2-Amino-2,6-dideoxy-D-glucitol-6-sulfonic acid is an analog of 2-amino-2-deoxy-D-glucitol 6-phosphate (GlcN-ol-6-P), a known inhibitor of GlcN-6-P synthase, in which the phosphate group of the latter is replaced with a sulfonate function. The compound obtained is a potential antifungal agent.

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Kornelia Skarbek

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Category:: Monographic publication
Type:: rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
Title of issue:: PhD Interdisciplinary Journal. No. 2 strony 89 - 92
Language:: English
Publication year:: 2013
Bibliographic description:: Skarbek K.: Synthesis of 2-amino-2,6-dideoxy-D-glucitol-6-sulfonic acid as a potential antifungal agent.// PhD Interdisciplinary Journal. No. 2/ ed. M. Czubenko Gdańsk: Gdańsk University of technology 2013, 2013, s.89-92
Verified by:: Gdańsk University of Technology