Synthesis, Structure, and Stability of Copper(II) Complexes Containing Imidazoline-Phthalazine Ligands with Potential Anticancer Activity

Łukasz Balewski; Iwona Inkielewicz-Stępniak; Maria Gdaniec; Katarzyna Turecka; Anna Hering; Anna Ordyszewska; Anita Kornicka

doi:10.3390/ph18030375

Synthesis, Structure, and Stability of Copper(II) Complexes Containing Imidazoline-Phthalazine Ligands with Potential Anticancer Activity

Abstract

Recently, there has been great interest in metallopharmaceuticals as potential anticancer agents. In this context, presented studies aim to synthesize and evaluate of two copper(II) complexes derived from phthalazine- and imidazoline-based ligands against on three human cancer cell lines: cervix epithelial cell line (HeLa), breast epithelial-like adenocarcinoma (MCF-7), and triple–negative breast epithelial cancer cell line (MDA-MB-231), as well as non-tumorigenic cell line (HDFa). Moreover their antimicrobial, and antioxidant properties were assessed.

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Authors (7)

Łukasz Balewski dr. inż.
Iwona Inkielewicz-Stępniak
Maria Gdaniec
Katarzyna Turecka
Anna Hering
Anna Ordyszewska dr inż.
Anita Kornicka

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Articles

Type:

artykuły w czasopismach

Published in:

Pharmaceuticals no. 18,
ISSN: 1424-8247

Language:

English

Publication year:

2025

Bibliographic description:

Balewski Ł., Inkielewicz-Stępniak I., Gdaniec M., Turecka K., Hering A., Ordyszewska A., Kornicka A.: Synthesis, Structure, and Stability of Copper(II) Complexes Containing Imidazoline-Phthalazine Ligands with Potential Anticancer Activity// Pharmaceuticals -,iss. 3 (2025), s.375-

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