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Abstract
In order to obtain a potential chemotherapeutic which is not affected on the normal BALB/3T3 cell line, a new arene ruthenium(II) complex {[RuCl(L1)(η6-p-cymene)]PF6}2 · H2O has been synthesized by a direct reaction of precursor, [{(η6-p-cymene)Ru(μ-Cl)}2Cl2], with N,N-chelating ligand (L1 - 2,2′-bis(4,5-dimethylimidazole). The compound has been fully characterized by elemental analysis, X-ray diffraction, IR, UV–Vis and 1H, 13C NMR spectroscopies. X-ray analysis have confirmed that the compound crystallized in the monoclinic group Cc as an inversion twin. The asymmetric unit contains two symmetrically independent cationic complexes [RuCl(L1)(η6-p-cymene)]+ whose charge is balanced by two PF6− counterions. The shape of each cationic coordination polyhedral can be described as a distorted dodecahedron and shows a typical piano-stool geometry. In addition, an analysis of the crystal structure and the Hirshfeld surface analysis were used to detect and visualize important hydrogen bonds and intermolecular interaction. Moreover, the antiproliferative behavior of the obtained complex was assayed against three human cells: MV-4-11, LoVo, MCF-7 and BALB/3T3 - normal mice fibroblast cells. To predict a binding mode, a potential interaction of ruthenium complex with calf thymus DNA (CT-DNA) has been explored using UV absorption and circular dichroism (CD).
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Authors (6)
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Agnieszka Gilewska
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Joanna Masternak dr
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Trynda Justyna
- Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
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Joanna Wietrzyk
- Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
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Barbara Barszcz dr hab.
- Institute of Chemistry, Jan Kochanowski University in Kielce
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF MOLECULAR STRUCTURE
no. 1155,
pages 288 - 296,
ISSN: 0022-2860 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Gilewska A., Masternak J., Kazimierczuk K., Justyna T., Wietrzyk J., Barszcz B.: Synthesis, structure, DNA binding and anticancer activity of mixed ligand ruthenium(II) complex// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 1155, (2018), s.288-296
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.molstruc.2017.10.105
- Verified by:
- Gdańsk University of Technology
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