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Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction
Abstract
The anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position 3. The compounds were synthesized via classical reactions such as nucleophilic substitution, solvent lysis, and condensation. Biological evaluation revealed that 3-(1-naphthylmethyl)-4-phenyl-5,6,7,8-tetrahydro-1H-quinolin-2-one (4a) exhibited potent cytotoxicity toward colon (HTC-116) and lung (A549) cancer cell lines. Analysis of the mechanism of action of compounds showed that compound 4a induced cell cycle arrest at the G2/ M phase, leading to apoptotic cell death via intrinsic and extrinsic pathways. Taken together, the findings of the study suggest that tetrahydroquinolinone derivatives bearing a carbonyl group at position 2 could be potential lead compounds to develop anticancer agents for the treatment of lung cancers
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Authors (5)
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Małgorzata Ryczkowska
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Natalia Maciejewska mgr inż
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-022-23640-9
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Scientific Reports
no. 12,
ISSN: 2045-2322 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Ryczkowska M., Maciejewska N., Olszewski M., Witkowska M., Makowiec S.: Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction// Scientific Reports -Vol. 12,iss. 1 (2022), s.19076-
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-022-23640-9
- Sources of funding:
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- COST_FREE
- Verified by:
- Gdańsk University of Technology
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