The methylome and transcriptome of fetal skin: implications for scarless healing

Justyna Podolak-Popinigis; Anna Ronowicz; Monika Dmochowska; Agnieszka Jakubiak; Paweł Sachadyn

doi:10.2217/epi-2016-0068

The methylome and transcriptome of fetal skin: implications for scarless healing

Abstract

Aim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated with inflammatory response and hyaluronate degradation showed increased DNA methylation before the transition, while those involved in embryonic morphogenesis, neuron differentiation and synapse functions did so after. A number of the methylome alterations were retained until adulthood and correlated with gene expression, while the functional associations imply that scarless healing depends on epigenetic regulation.

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Authors (5)

Justyna Podolak-Popinigis dr inż.
Anna Ronowicz
- Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej Katedra i Zakład Biologii i Botaniki Farmaceutycznej
Monika Dmochowska
- Gdański Uniwersytet Medyczny Trójmiejska Akademicka Zwierzętarnia Doświadczalna - Centrum Badawczo-Usługowe
Agnieszka Jakubiak
- Gdański Uniwersytet Medyczny Trójmiejska Akademicka Zwierzętarnia Doświadczalna - Centrum Badawczo-Usługowe
Paweł Sachadyn prof. dr hab. inż.

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DOI:: Digital Object Identifier (open in new tab) 10.2217/epi-2016-0068
License: Copyright (2016 Future Medicine Ltd)

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: EPIGENOMICS-UK no. 8, edition 10, pages 1331 - 1345,
ISSN: 1750-1911
Language:: English
Publication year:: 2016
Bibliographic description:: Podolak-Popinigis J., Ronowicz A., Dmochowska M., Jakubiak A., Sachadyn P.: The methylome and transcriptome of fetal skin: implications for scarless healing// EPIGENOMICS-UK. -Vol. 8, iss. 10 (2016), s.1331-1345
DOI:: Digital Object Identifier (open in new tab) 10.2217/epi-2016-0068
Verified by:: Gdańsk University of Technology