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Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: current status of studies
Abstract
Toxoplasma gondii is a parasitic protozoan which is the cause of toxoplasmosis. Although human toxoplasmosis in healthy adults is usually asymptomatic, serious disease can occur in the case of congenital infections and immunocompromised individuals. Furthermore, despite the exact recognition of its etiology, it still presents a diagnostic problem. Diagnosis of toxoplasmosis is mainly based on the results of serological tests detecting anti-T. gondii-specific antibodies in the patient’s serum sample. The specificities and sensitivities of serology tests depend mostly on the diagnostic antigen(s) used. Most of the commercial serological kits currently available are based on Toxoplasma lysate antigens (TLAs). In recent years, many studies showed that recombinant antigenic proteins of T. gondii may be an alternative source of antigens which are very useful for the serodiagnosis of toxoplasmosis. This article presents a review of current studies on the application and usefulness of different T. gondii recombinant antigens in serological tests for the diagnosis of human toxoplasmosis.
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- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1128/cvi.00117-13
- License
- Copyright (2013 American Society for Microbiology)
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Clinical and Vaccine Immunology
no. 20,
pages 1343 - 1351,
ISSN: 1556-6811 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Holec-Gąsior L.: Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: current status of studies// Clinical and Vaccine Immunology. -Vol. 20, nr. 9 (2013), s.1343-1351
- DOI:
- Digital Object Identifier (open in new tab) 10.1128/cvi.00117-13
- Verified by:
- Gdańsk University of Technology
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