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Abstract
Interactions of VUV light and DNA samples in aqueous solutions are reported. The damage induced by such radiation is quantified by monitoring both loss of supercoiled DNA and formation of single and double strand breaks using agarose gel electrophoresis. Irradiations were performed using synchrotron VUV photons of 130, 150, 170 and 190 nm. VUV irradiation experiments revealed enhanced damage upon irradiation with 170 nm photons as compared with irradiations with photons of 150 nm and 130 nm. Irradiations carried at 190 nm caused the least damage.
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Authors (7)
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Malgorzata Śmialek
- The Open University, Department of Physics and Astronomy
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Søren Hoffmann
- University of Aarhus, Institute for Storage Ring Facilities
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M Folkard
- Mount Vernon Hospital Gray Cancer Institute
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Kevin Prise
- Queen's University Belfast, Centre for Cancer Research and Cell Biology,
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David E.g. Shuker
- The Open University, Department of Chemistry and Analytical Sciences,
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N Braithwaite
- The Open University, Department of Physics and Astronomy
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Nigel J. Mason
- The Open University, Department of Physics and Astronomy
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- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1088/1742-6596/101/1/012020
- License
- Copyright (2008 IOP Publishing Ltd)
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Details
- Category:
- Articles
- Type:
- publikacja w in. zagranicznym czasopiśmie naukowym (tylko język obcy)
- Published in:
-
Journal of Physics : Conference Series
no. 101,
pages 1 - 9,
ISSN: 1742-6588 - Language:
- English
- Publication year:
- 2008
- Bibliographic description:
- Śmialek M., Hoffmann S., Folkard M., Prise K., Shuker D., Braithwaite N., Mason N.. VUV irradiation studies of plasmid DNA in aqueous solution. Journal of Physics : Conference Series, 2008, Vol. 101, , s.1-9
- DOI:
- Digital Object Identifier (open in new tab) 10.1088/1742-6596/101/1/012020
- Verified by:
- Gdańsk University of Technology
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