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• Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents

  Publication

  • J. M. Walczak
  • D. Iwaszkiewicz-Grześ
  • M. Ziomkowska
  • M. Śliwka-Kaszyńska
  • M. Daśko
  • P. Trzonkowski
  • G. Cholewiński

  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - Year 2022

  The group of new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5'-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis employed uronium-type activating system (TBTU/HOBt/DIPEA) while or phosphonic acid anhydride method (T3P/Py) facilitating amides to be obtained in moderate to excellent yields without...

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