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• Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease

  Publication

  • M. Przybyłowska
  • K. Dzierzbicka
  • K. Szymon
  • S. Demkowicz
  • M. Daśko
  • I. Inkielewicz-Stępniak

  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - Year 2022

  In this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...

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