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• In vivoevaluation of the CB1allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects

  Publication

  • T. Olszewska
  • M. Mohammed
  • G. Donvito
  • L. Moncayo
  • A. Swafford
  • J. Poklis
  • R. Grauer
  • B. Ignatowska-Jankowska
  • D. A. Kendall
  • D. Lu
  • A. H. Lichtman

  - PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR - Year 2020

  In the present study, we examined whether LDK1258, which produces strong CB1receptor allosteric effects ininvitroassays, would elicitin vivoeffects consistent with allosteric activity. In initial studies, LDK1258 reducedfood consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciaticnerve (CCI) model of neuropathic pain, which unexpectedly emerged 4 h post-injection. UPLC-MS/MS analysisquantified...

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