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• Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

  Publication

  • Y. Adar
  • M. Stark
  • E. E. Bram
  • P. Nowak-Sliwinska
  • H. van den Bergh
  • G. Szewczyk
  • T. Sarna
  • A. Skladanowski
  • A. Griffoen
  • Y. G. Assaraf

  - Cell Death and Disease - Year 2012

  Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...

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