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• Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein

  Publication

  • M. Jelen
  • I. Grochowina
  • A. Grabinska-Rogala
  • S. Ciesielski
  • K. Dabrowska
  • B. Tomiczek
  • Ł. Nierzwicki
  • W. Delewski
  • B. Schilke
  • J. Czub... and 4 others

  - JOURNAL OF MOLECULAR BIOLOGY - Year 2023

  Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis drives conformational changes in Hsp70 that stabilize substrate binding. However, because of the transient nature of substrate and JDP...

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