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• Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis

  Publication

  • A. Kokotkiewicz
  • M. Łuczkiewicz
  • J. Pawłowska
  • P. Łuczkiewicz
  • P. Sowiński
  • J. Witkowski
  • E. Bryl
  • A. Buciński

  - FITOTERAPIA - Year 2013

  A fast and efficient method for the isolation of the C-glucosidated xanthones mangiferin and isomangiferin from the South-African plant Cyclopia genistoides was developed for the first time. Two benzophenone derivatives: 3-C-β-glucosides of maclurin and iriflophenone, were isolated from C. genistoides extracts using semi-preparative. The structures of the compounds were determined by 1D and 2D NMR experiments and/or LC-DAD-ESI–MS.

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