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• Approaches Towards Better Immunosuppressive Agents

  Publication

  • J. M. Walczak
  • D. Iwaszkiewicz-Grześ
  • G. Cholewiński

  - CURRENT TOPICS IN MEDICINAL CHEMISTRY - Year 2024

  Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophe-nolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs...

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