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Search results for: Sulfamethizole

• Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

  Publication

  • P. Cysewski
  • M. Przybyłek
  • R. Rozalski

  - Materials - Year 2021

  Solubility enhancement of poorly soluble active pharmaceutical ingredients is of crucial importance for drug development and processing. Extensive experimental screening is limited due to the vast number of potential solvent combinations. Hence, theoretical models can offer valuable hints for guiding experiments aimed at providing solubility data. In this paper, we explore the possibility of applying quantum-chemistry-derived...

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• Experimental and theoretical studies on the Sulfamethazine-Urea and Sulfamethizole-Urea solid-liquid equilibria

  Publication

  • P. Cysewski
  • P. Walczak
  • D. Ziółkowska
  • I. Grela
  • M. Przybyłek

  - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY - Year 2021

  The miscibility of active pharmaceutical ingredients with excipients is an important aspect in pharmaceutical technology protocols. In this study, the differential scanning calorimetry (DSC) was used for Sulfamethazine-Urea (SI–U) and Sulfamethizole-Urea (SO–U) solid-liquid phase diagrams determination. Both sulfonamides form simple binary eutectics with Urea. The lack of new co-crystal phase formation was confirmed by inspection...

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