Search
Best results in : Research Potential Pokaż wszystkie wyniki (2)
Search results for: acylation
-
Katedry Chemii Organicznej
Research PotentialSynteza nowych związków organicznych w szczególności posiadających aktywność biologiczną. Opracowywanie i sprawdzanie w praktyce nowych metod syntezy związków organicznych. Inżynieria kryształów oraz zastosowanie dichroizmu kołowego. Badanie czynności optycznej związków konfiguracyjnie labilnych.
-
Katedra Chemii Analitycznej
Research PotentialZespół naukowo-badawczy z Katedry Chemii Analitycznej prowadzi badania podstawowe w zakresie: -opracowania nowych procedur analitycznych przeznaczonych do wykrywania, identyfikacji oraz oznaczenia szerokiego spectrum analitów w próbkach różnego typu materiałów charakteryzujących się złożonym a często także zmiennym składem matrycy, -budowy i badań charakterystyki analitycznej nowych typów elektronicznych nosów, -oszacowania wpływu...
Other results Pokaż wszystkie wyniki (9)
Search results for: acylation
-
Syntheses of N-Substituted Thymine Thioacetamides. A Novel Approach to Site Selective Acylation of Diaminoalkanes
PublicationA new series of N-substituted thiocarbamoyl derivs. contg. histamine, tryptamine, and other moieties having at least one amino group attached to an aliph. chain has been synthesized from (1-thyminyl)thioacetamide in good isolated yields (69-86%). N-[2-(4-Imidazolyl)ethyl](1-thyminyl)thioacetamide was hydrolyzed to its amide on prolonged heating in water. Ammonium sulfide (20-22% soln. in water) has found interesting new applications...
-
TMSCl Promoted Acylation of Amines with 5-(α-amino- α'-hydroxy)methylene Meldrum's Acids - Elucidation of Mechanism.
PublicationRecently we have observed accelerating influence of trimethyl silyl chloride addition on the rate of the reactions of 5-(α-amino- α'-hydroxy)methylene Meldrum's Acids with amines, particularly in the case of highly basic amines. However the nature of the aforementioned process remain unexplained. In proposed communication we wish to report insightful elucidation of this mechanism. The reaction under investigation involves simply...
-
TMSCL as a rate accelerating additive in acylations of amines with 5-(α- amino-α'-hydroxy)methylene meldrum's acids
PublicationAspects are presented of the acylation of amines, alcohols and thiols with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids. We placed special emphasis on the acylation reaction of secondary amines with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids, which, due to their basicity, caused problems concerning salt formation with a Meldrum acid derivative. We found that secondary amines, which react at the slowest rate and with a...
-
Configurational and Conformational Preferences in Stereoselective Acylations of N-Methyl-1,3-diaminopropane with Acyl Chlorides
PublicationEvidence for a stereoinduction profile of the reaction of N-methyl-1,3-diaminopropane with acyl chlorides was provided. A possibility to engage in intramol. CH2···HN and Cl···H-N interactions and the proton migration process to the methylamino group leads to the E secondary amides carrying the N···H+···N or N-H···N bridges, that show unusual spectroscopic images. Empirical relations between the ΔδC chem. shift differences,...
-
Tmscl as a rate accelerating additive in acylations of amines with 5-(α-amino- α'-hydroxy)methylene meldrum's acids
PublicationAspects are presented of the acylation of amines, alcohols and thiols with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids. We placed special emphasis on the acylation reaction of secondary amines with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids, which, due to their basicity, caused problems concerning salt formation with a Meldrum acid derivative. We found that secondary amines, which react at the slowest rate and with a...