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Search results for: lpxc
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Zespół Inżynierii Biomedycznej
Research Potential1. Komputerowo wspomagana analiza powierzchni ciała człowieka oraz mechaniki układu oddechowego; 2. Automatyzacja oceny stanu układu pokarmowego człowieka.
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Katedra Mechatroniki i Inżynierii Wysokich Napięć
Research Potential* Precyzyjna estymacja powierzchni ciała człowieka * Analiza biosygnałów * Systemy rehabilitacyjne * Analiza wpływu pól elektromagnetycznych na organizmy żywe * Elektro-mechaniczne struktury periodyczne jako aktywne akustycznie metamateriały * Właściwości elektro-mechaniczne materiałów dielektrycznych w różnych warunkach środowiskowych * Prądy upływu w diagnostyce ochronników przepięciowych * Roboty mobilne do diagnostyki linii...
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Zespół badawczo-rozwojowy systemów hydroakustycznych
Research Potential* systemy hydroakustyczne (nawigacyjne, echolokacyjne i komunikacyjne) * przetworniki ultradźwiękowe i anteny hydroakustyczne * propagacja fal akustycznych w morzu i wodach śródlądowych * prowadzone są również prace badawcze w zakresie akustyki teoretycznej, przetwarzania sygnałów analogowych i cyfrowych i techniki ultradźwiękowej * Katedry ma bogate, wieloletnie doświadczenie w budowie systemów hydroakustycznych, poczynając od...
Other results Pokaż wszystkie wyniki (17)
Search results for: lpxc
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Molecular basis of essentiality of early critical steps in the lipopolysaccharide biogenesis in Escherichia coli K-12: requirement of MsbA, cardiolipin, LpxL, LpxM and GcvB
PublicationTo identify the physiological factors that limit the growth of Escherichia coli K-12 strains synthesizing minimal lipopolysaccharide (LPS), we describe the first construction of strains devoid of the entire waa locus and concomitantly lacking all three acyltransferases (LpxL/LpxM/LpxP), synthesizing minimal lipid IVA derivatives with a restricted ability to grow at around 21 °C. Suppressors restoring growth up to 37 °C of Δ(gmhD-waaA)...
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Escherichia coli K-12 suppressor-free mutants lacking early glycosyltransferases and late acyltransferases. Minimal lipopolysaccharide structure and induction of envelope stress response.
PublicationTo elucidate the minimal lipopolysaccharide (LPS) structure needed for the viability of Escherichia coli, suppressor-free strains lacking either the 3-deoxy-d-manno-oct-2-ulosonic acid transferase waaA gene or derivatives of the heptosyltransferase I waaC deletion with lack of one or all late acyltransferases (lpxL/M/P) and/or various outer membrane biogenesis factors were constructed. Δ(waaC lpxL lpxM lpxP) and waaA mutants exhibited...
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A new factor LapD is required for the regulation of LpxC amounts and lipopolysaccharide trafficking
PublicationLipopolysaccharide (LPS) constitutes the major component of the outer membrane and is essential for bacteria, such as Escherichia coli. Recent work has revealed the essential roles of LapB and LapC proteins in regulating LPS amounts; although, if any additional partners are involved is unknown. Examination of proteins co-purifying with LapB identified LapD as a new partner. The purification of LapD reveals that it forms a complex...
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Suppressors of lapC mutation identify new regulators of LpxC, which mediates the first committed step in lipopolysaccharide biosynthesis
PublicationGram-negative bacteria, such as Escherichia coli, are characterized by an asymmetric outer membrane (OM) with lipopolysaccharide (LPS) located in the outer leaflet and phospholipids facing the inner leaflet. E. coli recruits LPS assembly proteins LapB, LapC and LapD in concert with FtsH protease to ensure a balanced biosynthesis of LPS and phospholipids. We recently reported that bacteria either lacking the periplasmic domain of...
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Regulation of the First Committed Step in Lipopolysaccharide Biosynthesis Catalyzed by LpxC Requires the Essential Protein LapC (YejM) and HslVU Protease
PublicationWe previously showed that lipopolysaccharide (LPS) assembly requires the essential LapB protein to regulate FtsH-mediated proteolysis of LpxC protein that catalyzes the first committed step in the LPS synthesis. To further understand the essential function of LapB and its role in LpxC turnover, multicopy suppressors of ΔlapB revealed that overproduction of HslV protease subunit prevents its lethality by proteolytic degradation...