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dr hab. Daniel Gackowski
Employment
- 2019 - present Professor at Department of Clinical Biochemistry
- 2003 - 2019 Associate professor at Department of Clinical Biochemistry, Collegium Medicum in Bydgoszcz
- 1998 - 1999 technician at Department of Clinical Biochemistry
Research fields
- No data
Publications
Filters
total: 70
Catalog Publications
Year 2021
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Analysis of 5-Hydroxymethyluracil Levels Using Flow Cytometry
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Mass Spectrometry-Based Analysis of DNA Modifications: Potential Applications in Basic Research and Clinic
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Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Bases
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Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS)
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Year 2020
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5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively
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Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
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Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression
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Year 2019
Year 2018
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Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
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Correction: Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy
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ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation
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Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice
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Systemowa równowaga antyoksyacyjna u pacjentów bez klinicznej manifestacji miażdżycy
Publication
Year 2017
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Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5-hydroxymethyl-2′-deoxycytidine level in cultured cancerous cell lines
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Systemic oxidoreductive balance and vascular function in individuals without clinical manifestation of atherosclerosis
Publication
Year 2016
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Accurate, Direct, and High-Throughput Analyses of a Broad Spectrum of Endogenously Generated DNA Base Modifications with Isotope-Dilution Two-Dimensional Ultraperformance Liquid Chromatography with Tandem Mass Spectrometry: Possible Clinical Implication
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Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
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Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine
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Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients
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Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA
Publication
Year 2015
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Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships
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Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer
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Year 2014
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8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients
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Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
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Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm1
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Epigenetic modifications and NF-κB pathway activity in Cu,Zn-SOD-deficient mice
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Viral infection-oxidative stress/DNA damage-aberrant DNA methylation: separate or interrelated events responsible for genetic instability and childhood ALL development?
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Year 2013
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Comparison of Oxidative Stress/DNA Damage in Semen and Blood of Fertile and Infertile Men
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Does morphology of carotid plaque depend on patient's oxidative stress?
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Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2′-deoxyguanosine
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Year 2012
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Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study
Publication
Year 2011
Year 2010
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Aberrant repair of etheno–DNA adducts in leukocytes and colon tissue of colon cancer patients
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Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients
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Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease
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Toward consensus in the analysis of urinary 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine as a noninvasive biomarker of oxidative stress
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Year 2009
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Elevated level of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls
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Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine
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Selenium Supplementation Reduced Oxidative DNA Damage in Adnexectomized BRCA1 Mutations Carriers
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Year 2008
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Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis
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Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
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Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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Year 2007
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Effects of basal level of antioxidants on oxidative DNA damage in humans
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Higher Leukocyte 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and Lower Plasma Ascorbate in Aging Humans?
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Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns
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