Michał Szymankiewicz - Publications - Bridge of Knowledge

Michał Szymankiewicz

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Year 2024

Solubility enhancement of metronidazole using natural deep eutectic solvents: Physicochemical and thermodynamic studies
Publication
- A. Szewczyk
- D. Warmińska
- J. Ruszkowski
- M. Szymankiewicz
- M. Prokopowicz
- JOURNAL OF MOLECULAR LIQUIDS - Year 2024
This research aimed to explore the utility of natural deep eutectic solvents (NADES) as the co-solvents for slightly water-soluble metronidazole (MNZ). After testing 70 wt% (percentage by weight) aqueous mixtures of seven NADESs, it was found that MNZ had the highest solubility in water solutions of NADES composed of choline chloride (ChCl) and citric acid (CA). The solubility of MNZ (expressed as 103 mol fraction) increased with...

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