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Study of the ability of TXT-compounds to promote telomeric G4 DNA thermal stabilization using FRET melting assay
Description
The data set contains a DNA melting screen obtained from the FRET melting assay. Thermal stabilities of G-quadruplex structures were analysed in the presence and in absence of ligands. TMPyP4 and MTX were used as references. Measurements were carried out in triplicate using a LightCycler 480 thermocycler (Roche Life Science) with a filter setting of 465 nm/510 nm at 30–95°C with a rate of 0.01°C/s.
Dataset file
FRET melting assay_TXT1-4 compounds.zip
1.5 MB,
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4123651be400709937d7c95ea8a33d36-1,
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File details
- License:
-
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CC BY-NC-SANon-commercial - Share-alike - Raw data:
- Data contained in dataset was not processed.
Details
- Year of publication:
- 2022
- Verification date:
- 2023-03-24
- Dataset language:
- English
- Fields of science:
-
- biological sciences (Natural sciences)
- DOI:
- DOI ID 10.34808/c3kr-qs15 open in new tab
- Funding:
- Verified by:
- Gdańsk University of Technology
Keywords
References
- publication Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
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