Search results for: G4

• Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail

  Publication

  • M. Kogut
  • C. Kleist
  • J. Czub

  - PLoS Computational Biology - Year 2019

  G-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...

  Full text available to download

• Study of the ability of TXT-compounds to promote telomeric G4 DNA thermal stabilization using FRET melting assay

  Open Research Data

  open access

  • N. Maciejewska

  The data set contains a DNA melting screen obtained from the FRET melting assay. Thermal stabilities of G-quadruplex structures were analysed in the presence and in absence of ligands. TMPyP4 and MTX were used as references. Measurements were carried out in triplicate using a LightCycler 480 thermocycler (Roche Life Science) with a filter setting of...

• Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene

  Publication

  • B. Masojć
  • M. Mierzejewski
  • C. Cybulski
  • T. van
  • T. Dębniak
  • B. Górski
  • E. Jaworowska
  • C. Tarnowska
  • M. Lenner
  • R. Scott
  • J. Lubiński

  - BREAST CANCER RESEARCH AND TREATMENT - Year 2006

  Full text to download in external service

• Przyrządy do oceny jakości energii elektrycznej na przyykładzie elspec g4500

  Publication

  • M. Olesz

  - Year 2009

  W artykule opisano przyrząd nowej generacji w dziedzinie pomiarów jakości energii elektrycznej typu ELSPEC G4500. Urządzenie pracujące w klasie A wprowadza nowy standard pomiarów polegający na wykonywaniu ciągłej rejestracji wszystkich interesujących użyt-kownika sygnałów. Zastosowane rozmiary pamięci i sposoby kompresji danych umożliwiają zapis na-wet wieloletniej obserwacji zjawisk zachodzących w sieci elektrycznej. Dane te...

• Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA

  Publication

  • M. Kogut
  • C. Kleist
  • J. Czub

  - NUCLEIC ACIDS RESEARCH - Year 2016

  G-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...

  Full text available to download

• Why Are Left-Handed G-Quadruplexes Scarce?

  Publication

  • M. Jurkowski
  • M. Kogut
  • S. Sappati
  • J. Czub

  - Journal of Physical Chemistry Letters - Year 2024

  G-quadruplexes (G4s) are nucleic acid structures crucial for the regulation of gene expression and genome maintenance. While they hold promise as nanodevice components, achieving desired G4 folds requires understanding the interplay between stability and structural properties, like helicity. Although right-handed G4 structures dominate the experimental data, the molecular basis for this preference over left-handed helicity is unclear....

  Full text available to download

• Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations

  Publication

  • K. A. Hossain
  • M. Jurkowski
  • J. Czub
  • M. Kogut

  - Computational and Structural Biotechnology Journal - Year 2021

  Because of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by recognizing and unwinding parallel G4s. Here, we studied the molecular basis for the high affinity and specificity of DHX36 for parallel-type...

  Full text available to download

• Rola geosiatek Tensar przy wzmacnianiu słabych podłoży gruntowych pod nawierzchniami ulepszonymi

  Publication

  • J. Judycki

  - Year 2005

  Kiedy konstrukcje nawierzchni projektuje się na słabych gruntach, wzmocnienia przy użyciu geosiatek są jedną z najlepszych opcji.Za krytyczną wartość wskaźnika nośności podłoża gruntowego uznaje się najczęściej CBR <2,5. Katalogo typowych nawierzchni [1,2] zalecają jednak zastosowanie geosyntetyków nawet dla podłoży grupy nośności G3 i G4 (przy CBR <5) w celu uzyskania bardziej efektywnego ekonomicznie rozwiązania. Jeżeli geosiatki...

• Neoplasm, malignant - Female, 59 - Tissue image [12090630030143671]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Female, 59 - Tissue image [12090630030148061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Female, 59 - Tissue image [12090630030142951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 53 - Tissue image [2220630014963711]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 76 - Tissue image [2260630006666841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 68 - Tissue image [12170630008606261]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 59 - Tissue image [2210630020356151]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 59 - Tissue image [2210630020359421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 53 - Tissue image [2220630014961311]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 68 - Tissue image [12170630008602081]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Female, 59 - Tissue image [12090630030143101]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 68 - Tissue image [12170630008603031]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 76 - Tissue image [2260630006662761]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 59 - Tissue image [2210630020355431]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 53 - Tissue image [2220630014967641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 59 - Tissue image [221063002035331]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 45 - Tissue image [2210630020356071]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 56 - Tissue image [12160630012631121]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 56 - Tissue image [12160630012636031]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 58 - Tissue image [2170630005865461]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 58 - Tissue image [2170630005868771]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 45 - Tissue image [2210630020352951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 56 - Tissue image [12160630012636691]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 58 - Tissue image [2170630005863811]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 58 - Tissue image [2170630005865641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Male, 58 - Tissue image [2170630005861321]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [527073002343701]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023431221]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 45 - Tissue image [2210630020359871]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 75 - Tissue image [12160630012638111]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 57 - Tissue image [12020630021661741]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [7040247104953231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023436541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 57 - Tissue image [12020630021664841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023436201]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 56 - Tissue image [12160630012638461]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023435181]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023437631]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, malignant - Female, 45 - Tissue image [2210630020354151]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 75 - Tissue image [12160630012633871]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 57 - Tissue image [12020630021663721]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Neoplasm, malignant - Male, 57 - Tissue image [12020630021662291]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.