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Search results for: G4
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
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Przyrządy do oceny jakości energii elektrycznej na przyykładzie elspec g4500
PublicationW artykule opisano przyrząd nowej generacji w dziedzinie pomiarów jakości energii elektrycznej typu ELSPEC G4500. Urządzenie pracujące w klasie A wprowadza nowy standard pomiarów polegający na wykonywaniu ciągłej rejestracji wszystkich interesujących użyt-kownika sygnałów. Zastosowane rozmiary pamięci i sposoby kompresji danych umożliwiają zapis na-wet wieloletniej obserwacji zjawisk zachodzących w sieci elektrycznej. Dane te...
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Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublicationG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
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Why Are Left-Handed G-Quadruplexes Scarce?
PublicationG-quadruplexes (G4s) are nucleic acid structures crucial for the regulation of gene expression and genome maintenance. While they hold promise as nanodevice components, achieving desired G4 folds requires understanding the interplay between stability and structural properties, like helicity. Although right-handed G4 structures dominate the experimental data, the molecular basis for this preference over left-handed helicity is unclear....
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Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations
PublicationBecause of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by recognizing and unwinding parallel G4s. Here, we studied the molecular basis for the high affinity and specificity of DHX36 for parallel-type...
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Rola geosiatek Tensar przy wzmacnianiu słabych podłoży gruntowych pod nawierzchniami ulepszonymi
PublicationKiedy konstrukcje nawierzchni projektuje się na słabych gruntach, wzmocnienia przy użyciu geosiatek są jedną z najlepszych opcji.Za krytyczną wartość wskaźnika nośności podłoża gruntowego uznaje się najczęściej CBR <2,5. Katalogo typowych nawierzchni [1,2] zalecają jednak zastosowanie geosyntetyków nawet dla podłoży grupy nośności G3 i G4 (przy CBR <5) w celu uzyskania bardziej efektywnego ekonomicznie rozwiązania. Jeżeli geosiatki...
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Unraveling the Interplay between DNA and Proteins: A Computational Exploration of Sequence and Structure-Specific Recognition Mechanisms
PublicationMy PhD dissertation focused on DNA-protein interactions and the recognition of specific DNA sequences and structures. I discovered that acidic amino acid residues (Asp/Glu) play a crucial role by exhibiting a preference for cytosine. Their contribution to binding affinity depends on nearby cytosines, balancing electrostatic repulsion with specific interactions. Acidic residues act as negative selectors, discouraging non-cytosine...
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Effect of Thermal Treatment of Birch Wood by Saturated Water Vapor on Granulometric Composition of Chips from Sawing and Milling Processes from the Point of View of Its Processing to Composites
PublicationThe goal of this work is to investigate the impact of thermal modification of birch wood with saturated steam on the particle size distribution of the sawing and milling process. Birch wood (Betula pendula Roth) is an excellent source to produce plywood boards. Wastes from mechanical processing of birch wood are suitable to produce composite materials. Granulometric analyses of chips from sawing processes on the PRW 15M frame saw,...