Paulina Gwarda - Publications - Bridge of Knowledge

Paulina Gwarda

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Year 2020

A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies
Publication
- T. Laskowski
- W. Andrałojć
- J. Grynda
- P. Gwarda
- J. Mazerski
- Z. Gdaniec
- Scientific Reports - Year 2020
Triazoloacridinone C-1305, a potent antitumor agent recommended for Phase I clinical trials, exhibits high activity towards a wide range of experimental colon carcinomas, in many cases associated with complete tumor regression. C-1305 is a well-established dsDNA intercalator, yet no information on its mode of binding into DNA is available to date. Herein, we present the NMR-driven and MD-refined reconstruction of the 3D structures...

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